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Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?

Published online by Cambridge University Press:  28 August 2019

Elda Gonçalves Santos ,
Reggiani V. Gonçalves Open the ORCID record for Reggiani V. Gonçalves [Opens in a new window] ,
Thaiany G. Souza-Silva ,
Izabel R. S. C. Maldonado ,
Eliziária C. Santos ,
André Talvani ,
Antônio J. Natali  and
Rômulo D. Novaes Open the ORCID record for Rômulo D. Novaes [Opens in a new window]
Elda Gonçalves Santos
Affiliation:
Department of Structural Biology, Institute of Biomedical Sciences, Universidade Federal de Alfenas, Alfenas, MG, 37130-001, Brazil
Reggiani V. Gonçalves
Affiliation:
Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil
Thaiany G. Souza-Silva
Affiliation:
Department of Structural Biology, Institute of Biomedical Sciences, Universidade Federal de Alfenas, Alfenas, MG, 37130-001, Brazil
Izabel R. S. C. Maldonado
Affiliation:
Department of General Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil
Eliziária C. Santos
Affiliation:
School of Medicine, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, 39100-000, Brazil
André Talvani
Affiliation:
Department of Biological Science and NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, 35400-000, Brazil
Antônio J. Natali
Affiliation:
Department of Physical Education, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil.
Rômulo D. Novaes*
Affiliation:
Department of Animal Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil
*
Author for correspondence: Rômulo Dias Novaes, E-mail: romuonovaes@yahoo.com.br, romulo.novaes@unifal-mg.edu.br
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Abstract

Considering a potential exercise-drug interaction, we investigated whether exercise training could improve the efficacy of specific antiparasitic chemotherapy in a rodent model of Chagas disease. Wistar rats were randomized into five groups: sedentary and uninfected (CT); sedentary and infected (SI); sedentary, infected and treated (SIT); trained and infected (TI); trained, infected and treated (TIT). After 9-weeks running training, the animals were infected with T. cruzi and followed up for 4 weeks, receiving 100 mg kg−1 day−1 benznidazole. No evidence of myocarditis was observed in CT animals. TI animals exhibited reduced parasitemia, myocarditis, and reactive tissue damage compared to SI animals, in addition to increased IFN-γ, IL-4, IL-10, heart non-protein antioxidant (NPA) levels and glutathione-s transferase activity (P < 0.05). The CT, SIT and TIT groups presented similar reductions in parasitemia, cytokines (IFN-γ, TNF-α, IL-4, IL-10, IL-17 and MCP-1), inflammatory infiltrate, oxidative heart damage and antioxidant enzymes activity compared to SI and TI animals, as well as reduced heart microstructural remodeling (P < 0.05). By modulating heart inflammation and redox metabolism, exercise training exerts a protective effect against T. cruzi infection in rats. However, the antiparasitic and cardioprotective effects of benznidazole chemotherapy are more pronounced, determining similar endpoints in sedentary and trained T. cruzi-infected rats.

Keywords

Cardiovascular pathologycomplementary therapyexperimental chemotherapyoxidative stressTrypanosoma cruzi
Type
Research Article
Information
Parasitology , Volume 146 , Issue 13 , November 2019 , pp. 1655 - 1664
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Copyright
Copyright © Cambridge University Press 2019 

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