Different source of commercial vegetable oils may regulate metabolic, inflammatory and redox status in healthy rats

https://doi.org/10.1016/j.jff.2020.103780Get rights and content
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Highlights

  • The vegetable oils intake induces changes in metabolic and inflammatory parameters.

  • Coconut oil induces glycometabolic and hepatic alterations in healthy rats.

  • Linseed oil reduces serum TAG and IL-6.

  • Sunflower oil increases superoxide dismutase and catalase activity and reduces total glutathione, IL-6 e TNF.

  • Sunflower oil increases hepatic lipogenesis and reduces serum lipids.

Abstract

Our goal was to carry out a comparative study to evaluate the metabolic and inflammatory effects and the redox status of commercial vegetable oils supplementation [linseed (LO), coconut (VCO), and sunflower (SO)] in metabolically healthy rats. The results found in this study showed that the LO group decreased the HOMA-IR and hepatic cholesterol, and increased the serum levels of IL-6. Supplementation with VCO increased glucose and HOMA-IR, cholesterol concentration and serum triacylglycerol (TAG). In this group, there was also an increase in TBARS. In the SO group there was a decrease in serum concentrations of cholesterol and TAG and an increase in hepatic concentration of these lipids. In addition, in the SO group there was a decrease in hepatic and serum concentrations of IL-6 and hepatic levels of TNF, as well as a decrease in the GSH/GSSG ratio, suggesting changes in glutathione metabolism and inflammatory mediators.

Keywords

Inflammation
Polyunsaturated fatty acid
Redox process
Saturated fatty acid
Vegetable oils

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