@article {26697,
	title = {Is lin28a polymorphism associated with endurance performance in soccer players?},
	journal = {SPORT SCIENCES FOR HEALTH },
	year = {2021},
	abstract = {
	Purpose



	The aim of this study was to investigate the association of rs6598964 (A \&gt; G), a molecular marker located in the\&nbsp;LIN28A\&nbsp;gene, with the performance of Brazilian soccer players using the VO2max predicted by performance in the Yo-Yo test as the phenotype.



	Methods



	The study sample comprised 227 male players on a team in the first division of Brazilian soccer distributed in the following categories: U15 (n = 67, VO2max = 52.75 {\textpm} 4.74\&nbsp;ml/kg/min), U17 (n = 43, VO2max = 54.37 {\textpm} 5.47\&nbsp;ml/kg/min), U20 (n = 79, VO2max = 54.97 {\textpm} 5.13\&nbsp;ml/kg/min), and Professional (n = 38, VO2max = 55.84 {\textpm} 4.37\&nbsp;ml/kg/min). Genotype models (codominance, A-recessive, A-dominant and overdominance models) were tested using Kruskal{\textendash}Wallis and Mann{\textendash}Whitney tests with Bonferroni correction for multiple comparisons tests.



	Results



	Significantly higher predicted VO2max was observed in individuals with the A/A genotype (VO2max = 62.12 {\textpm} 3.97\&nbsp;mL/kg/min) compared to both the A/G (53.44 {\textpm} 8.88\&nbsp;mL/kg/min) and G/G (52.44 {\textpm} 6.11\&nbsp;mL/kg/min) genotypes (p \&lt; 0.001). Model comparisons suggested the differences in predicted VO2max were best explained by the A-recessive model.



	Conclusion



	This study is the first to associate the\&nbsp;LIN28A\&nbsp;polymorphism with endurance performance in soccer players. However, further studies are needed to confirm the associations described here and to investigate how\&nbsp;LIN28A\&nbsp;interacts with other genes related to athletic performance.

},
	url = {https://doi.org/10.1007/s11332-021-00812-0},
	author = {T. Kanope and E. M. Pimenta and C. Veneroso and D. Coelho and L. F. Oliveira and E. Silami-Garcia and R. F. Morandi and M. R. S. Carvalho and I. C. Rosse}
}
