@article {26701,
	title = {Alpha-Actinin-3 R577X Polymorphism Influences Muscle Damage and Hormonal Responses After a Soccer Game},
	journal = {JOURNAL OF STRENGTH AND CONDITIONING RESEARCH},
	volume = {33},
	number = {10},
	year = {2019},
	pages = {2655-2664},
	abstract = {
	The purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples were collected immediately before, after, 2, and 4 hours after the games to assess muscle damage (creatine kinase [CK] and alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol, and testosterone). Postgame CK was higher as compared to the pregame values in both groups and it was also higher in the RR/RX (p\&nbsp;\&lt; 0.05) than in the XX. The concentrations of alpha-actin and IL-6 were similar for both groups and did not change over time. Testosterone was increased after the game only in the RR/RX group (p\&nbsp;\&lt; 0.05). Cortisol concentrations in group RR/RX were higher immediately after the game than before the game, and 2 and 4 hours after the game the concentration decreased (p\&nbsp;\&lt; 0.05). The RR and RX individuals presented higher markers of muscle microtrauma and hormonal stress, probably because they performed more speed and power actions during the game, which is a self-regulated activity. From the different responses presented by RR/RX and XX genotypes, we conclude that the genotypic profile should be taken into account when planning training workloads and recovery of athletes.

},
	url = {https://journals.lww.com/nsca-jscr/Abstract/2019/10000/Alpha_Actinin_3_R577X_Polymorphism_Influences.10.aspx},
	author = {Daniel B. COELHO and Eduardo M. PIMENTA and Rosse, Izinara C and Veneroso, Christiano and et. al.}
}
