Ana Paula Moreira Barboza

Andrade ÂL, Lima AM, Santos VR, da e Silva RCMF, Barboza APM, Neves BRA, Vasconcellos WA, Domingues RZ. Glass-ionomer-propolis composites for caries inhibition: flavonoids release, physical-chemical, antibacterial and mechanical properties. Biomedical Physics & Engineering Express [Internet]. 2019;5 (2) :027006. Publisher's VersionAbstract
The addition of propolis extract (PE) to the glass ionomer results in an adhesive material for restorative treatment, with interesting properties mainly due to the flavonoids contained in the propolis extract. However, no study of the flavonoid release profile in these materials was reported. This work studies the flavonoid release profile in such materials aiming to contribute to the future synthesis of optimized devices adept to prolong the efficacy of the drug. The study involved the synthesis and study of the physicochemical, antibacterial and mechanical properties of glass ionomer cement (GIC) and glass-ionomer-propolis composites (GIC-PE). The samples were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analyses. The released concentration of flavonoids, the antimicrobial activity and the compressive strength were also evaluated. Antimicrobial activity was assessed against Streptococcus mutans, Streptococcus salivarius, and Candida albicans, common pathogens in the mouth. The results indicate that the antibacterial activity of GIC-PE samples is closely correlated with the release of flavonoids. The method used to prepare the composite GIC-PE leads to an initial drug delivery burst effect able to diminish partially the population of bacteria tested. The mechanical properties and thermal stability of GIC-PE are higher than those of the GIC and are clearly related to its microstructure. This study is clinically significant because the addition of propolis extract (PE) to the GIC resulted in a novel differentiated product with enhanced mechanical and antimicrobial properties compared to the GIC.
Azevedo MLS, Silveira BM, Novack KM, Barboza APM, Neves BRA, M. R. dos Santos V. Study of Controlled Release of PMMA-g-PEG Copolymer and Derivatives Incorporated with the Indomethacin Drug. Macromolecular Symposia [Internet]. 2018;381 (1) :1800145. Publisher's VersionAbstract
Synthetic polymers are made up of repeated monomeric units, and this gives them a very versatile appearance, making them useful in many areas of science. One is the pharmaceutical, which correlates the properties of the polymer with the active principle, so they can be used as an excipient or in the controlled release system. The PMMA-g-PEG4000 has characteristics derived from its precursors, that are pharmacologically active. When we incorporate drugs into this structure, the polymer can act on the controlled release, lessening the toxic character of the drug and producing fewer side effects. In this work, incorporations of the drug indomethacin were made in the PMMA-g-PEG copolymer and derivatives (PMMA-g-PEG4000 ETIL and PMMA-g-PEG4000 ACET). The samples were characterized by infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), thermogravimetric analysis (TGA), and atomic force microscopy (AFM) measurements. For each sample, the controlled release was performed in a total time of 4 h and the efficiency of the modified structures was verified.
Barboza APM, Matos MJS, Chacham H, Batista RJC, de Oliveira AB, Mazzoni MSC, Neves BRA. Compression-Induced Modification of Boron Nitride Layers: A Conductive Two-Dimensional BN Compound. ACS Nano [Internet]. 2018 :null. Publisher's Version
Chacham H, Barboza APM, de Oliveira AB, de Oliveira CK, Batista RJC, Neves BRA. Universal deformation pathways and flexural hardening of nanoscale 2D-material standing folds. Nanotechnology [Internet]. 2018;29 (9) :095704. Publisher's VersionAbstract
In the present work, we use atomic force microscopy nanomanipulation of 2D-material standing folds to investigate their mechanical deformation. Using graphene, h-BN and talc nanoscale wrinkles as testbeds, universal force–strain pathways are clearly uncovered and well-accounted for by an analytical model. Such universality further enables the investigation of each fold bending stiffness κ as a function of its characteristic height h 0 . We observe a more than tenfold increase of κ as h 0 increases in the 10–100 nm range, with power-law behaviors of κ versus h 0 with exponents larger than unity for the three materials. This implies anomalous scaling of the mechanical responses of nano-objects made from these materials.
Fernandes TFD, Gadelha A, Barboza A, Paniago R, Campos LC, Guimaraes P, Assis P, Almeida Neves BR. Robust nanofabrication of monolayer MoS2 islands with strong photoluminescence enhancement via local anodic oxidation. 2D Materials [Internet]. 2018. Publisher's VersionAbstract
Abstract In this work, we demonstrate the nanofabrication of monolayer MoS2 islands using local anodic oxidation of few-layer and bulk MoS2 flakes. The nanofabricated islands present true monolayer Raman signal and photoluminescence intensity up to two orders of magnitude larger than that of a pristine monolayer. This technique is robust enough to result in monolayer islands without the need of meticulously fine-tuning the oxidation process, thus providing a fast and reliable way of creating monolayer regions with enhanced optical properties and with controllable size, shape, and position.
Versiani AF, Astigarraga RG, Rocha ESO, Barboza APM, Kroon EG, Rachid MA, Souza DG, Ladeira LO, Barbosa-Stancioli EF, Jorio A, et al. Multi-walled carbon nanotubes functionalized with recombinant Dengue virus 3 envelope proteins induce significant and specific immune responses in mice. Journal of Nanobiotechnology [Internet]. 2017;15 (1) :26. Publisher's VersionAbstract
Dengue is the most prevalent arthropod-borne viral disease in the world. In this article we present results on the development, characterization and immunogenic evaluation of an alternative vaccine candidate against Dengue.
Alencar AB, Barboza APM, Archanjo BS, Chacham H, Neves BRA. Experimental and theoretical investigations of monolayer and few-layer talc. 2d Materials [Internet]. 2015;2 (1). Publisher's Version
Araujo KAS, Barboza APM, Fernandes TFD, Shadmi N, Joselevich E, Mazzoni MSC, Neves BRA. Charge transfer between carbon nanotubes on surfaces. Nanoscale [Internet]. 2015;7 (39) :16175-16181. Publisher's Version
Malard LM, Alencar TV, Barboza APM, Mak KF, de Paula AM, Ieee. Imaging the crystal structure of few-layer two-dimensional crystals by optical nonlinearity. In: 2013 Conference on Lasers and Electro-Optics. ; 2013. Publisher's Version
Malard LM, Alencar TV, Barboza APM, Mak KF, de Paula AM. Observation of intense second harmonic generation from MoS2 atomic crystals. Physical Review B [Internet]. 2013;87 (20). Publisher's Version
Manhabosco TM, Barboza APM, Batista RJC, Neves BRA, Mueller IL. Corrosion, wear and wear-corrosion behavior of graphite-like a-C:H films deposited on bare and nitrided titanium alloy. Diamond and Related Materials [Internet]. 2013;31 :58-64. Publisher's Version
Archanjo BS, Barboza APM, Neves BRA, Malard LM, Ferreira EHM, Brant JC, Alves ES, Plentz F, Carozo V, Fragneaud B, et al. The use of a Ga+ focused ion beam to modify graphene for device applications. Nanotechnology [Internet]. 2012;23 (25). Publisher's Version
Barboza APM, Carara SS, Batista RJC, Chacham H, Neves BRA. Controlling the Electrical Behavior of Semiconducting Carbon Nanotubes via Tube Contact. Small [Internet]. 2012;8 (2) :220-224. Publisher's Version
Barboza APM, Chacham H, Oliveira CK, Fernandes TFD, Ferreira EHM, Archanjo BS, Batista RJC, Oliveira AB, Neves BRA. Dynamic Negative Compressibility of Few-Layer Graphene, h-BN, and MoS2. Nano Letters [Internet]. 2012;12 (5) :2313-2317. Publisher's Version
Barboza APM, Guimaraes MHD, Massote DVP, Campos LC, Barbosa Neto NM, Cancado LG, Lacerda RG, Chacham H, Mazzoni MSC, Neves BRA. Room-Temperature Compression-Induced Diamondization of Few-Layer Graphene. Advanced Materials [Internet]. 2011;23 (27) :3014-+. Publisher's Version
Soares JS, Barboza APM, Araujo PT, Barbosa Neto NM, Nakabayashi D, Shadmi N, Yarden TS, Ismach A, Geblinger N, Joselevich E, et al. Modulating the Electronic Properties along Carbon Nanotubes via Tube-Substrate Interaction. Nano Letters [Internet]. 2010;10 (12) :5043-5048. Publisher's Version
Barboza APM, Gomes AP, Chacham H, Neves BRA. Probing electric characteristics and sorting out metallic from semiconducting carbon nanotubes. Carbon [Internet]. 2010;48 (11) :3287-3292. Publisher's Version
Barboza APM, Chacham H, Neves BRA. Universal Response of Single-Wall Carbon Nanotubes to Radial Compression. Physical Review Letters [Internet]. 2009;102 (2). Publisher's Version
Barboza APM, Gomes AP, Archanjo BS, Araujo PT, Jorio A, Ferlauto AS, Mazzoni MSC, Chacham H, Neves BRA. Deformation induced semiconductor-metal transition in single wall carbon nanotubes probed by electric force microscopy. Physical Review Letters [Internet]. 2008;100 (25). Publisher's Version